Antacid Compounds
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Sucralfate

Al8(OH)16(C12H14O35S8) [Al(OH)3]x [H2O]y  

Sucralfate is the basic aluminium salt of sucrose octasulfate (SOS). The therapeutic effect of Sucralfate in gastric complaints is based on an increase in the protective mechanisms of the mucous membranes in the stomach and duodenum against exogenous and endogenous aggressors.

The cytoprotective action of Sucralfate includes the neutralization of acid, the selective formation of a protective layer over eroded surface areas, specific protection of lesions and adsorption of pepsin and bile acids, resulting in inhibition of peptic activity.
 

Sucralfate Powder S 215 and S 225

Sucralfate S 215 powder is suitable for use in tablet formulations. Sucralfate S225 is a milled powder ideal for use in soft tablet and candy formulations or for powder mixtures intended for resuspending (powder sachets).

Type Assay Al Assay SOS Density (tapped) d50Pharmacopoeia
 S 215 15,5 - 18,5 [%] 30,0 - 38,0 [%]0,65 - 0,85 [g/ml]30 - 40 µm USP
 S 225 15,5 - 18,5 [%] 30,0 - 38,0 [%]0,30 - 0,48 [g/ml] 4 µm USP

Sucralfate Suspension S 611

Sucralfate S611 is a suspension with an active content of 30% Sucralfate. It is ideal for use in liquid antacid formulations.

Type Assay Assay SOS d50 Pharmacopoeia
 S611 4,7 - 6,0 [%] 8,3 - 13,4 [%] 4 - 6 µm USP